Interfacial and lipid transfer properties of human phospholipid transfer protein
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- 作者：Niko Setä ; lä ; Jari Metso ; Susanne Wiedmer ; Gebrenegus Yohannes ; Paavo Kinnunen ; Christian Ehnholm ; Juha Holopainen ; Matti Jauhiainen
- 关键词：Glycolipids ; Cell membrane ; Phase transition ; FTIR ; SAXS
- 刊名：Chemistry and Physics of Lipids
- 出版年：2007
- 出版时间：September 2007
- 年：2007
- 卷：149
- 期：Supplement 1
- 页码：S88-S89
- 全文大小：57 K
文摘
The structural preferences of 1,2-dioleoyl-sn-glycerol glycolipids with glucose, galactose, maltose, and cellobiose as sugar head group were investigated under near physiological conditions with Fourier-transform infrared spectroscopy (FT-IR) and synchrotron radiation small-angle X-ray scattering (SAXS). Whereas all glycolipids have a very high fluidity at temperatures above 0 °C, the mono- and disaccharide compounds differ considerably in their aggregate structures. The monosaccharide compounds adopt only inverted hexagonal (HII) structures in the temperature range 5–70 °C, while the disaccharide compounds adopt only multilamellar structures. Since these and similar glycolipids are frequently found in nature, these data should be of relevance for the function of their host cell membranes.