Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues
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- 作者：Mariagrazia Rosellia ; Alessia Caroccia ; alessia.carocci@uniba.it" class="auth_mail" title="E-mail the corresponding author ; Roberta Budriesib ; Matteo Micuccib ; Maddalena Tomaa ; Lorenzo Di Cesare Mannellic ; Angelo Lovecea ; Alessia Catalanoa ; Maria Maddalena Cavalluzzia ; Claudio Brunoa ; Annalisa De Palmad ; Marialessandra Continoa ; Maria Grazia Perronea ; Nicola Antonio Colabufoa ; Alberto Chiarinib ; Carlo Franchinia ; Carla Ghelardinic ; Solomon Habtemariame ; Giovanni Lentinia
- 关键词：Mexiletine ; Antiarrhythmics ; P-glycoprotein ; Inotropism ; MW-assisted synthesis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：300-307
- 全文大小：427 K
文摘
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Search for new antiarrhythmic agents.
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Antiarrhythmic effects evaluation of mexiletine analogues.
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Identification of potent and selective antiarrhythmic agents.