The BTBR T+tf/J mouse model for autism spectrum disorders-in search of biomarkers
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- 作者：Ksenia Z. Meyza ; Erwin B. Defensor ; Ashley L. Jensen ; Michael J. Corley ; Br ; on L. Pearson ; Roger L.H. Pobbe ; Valerie J. Bolivar ; D. Caroline Blanchard ; Robert J. Blanchard
- 关键词：BTBR T+tf/J mouse ; Autism spectrum disorder ; Social interaction ; Agenesis of corpus callosum ; Biomarkers
- 刊名：Behavioural Brain Research
- 出版年：2013
- 出版时间：15 August, 2013
- 年：2013
- 卷：251
- 期：Complete
- 页码：25-34
- 全文大小：666 K
文摘
Autism spectrum disorders (ASD) form a common group of neurodevelopmental disorders appearing to be under polygenic control, but also strongly influenced by multiple environmental factors. The brain mechanisms responsible for ASD are not understood and animal models paralleling related emotional and cognitive impairments may prove helpful in unraveling them. BTBR T+tf/J (BTBR) mice display behaviors consistent with the three diagnostic categories for ASD. They show impaired social interaction and communication as well as increased repetitive behaviors. This review covers much of the data available to date on BTBR behavior, neuroanatomy and physiology in search for candidate biomarkers, which could both serve as diagnostic tools and help to design effective treatments for the behavioral symptoms of ASD.