Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors
详细信息 查看全文
- 作者：Silke Kerscher-Hack ; Thejavathi Renukappa-Gutke ; Georg Hö ; fner ; Klaus T. Wanner ; klaus.wanner@cup.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：GABA uptake ; mGAT3 ; N-alkylimidazolealkanoic acids
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：852-880
- 全文大小：4488 K
文摘
- •
New series of N-alkylated imidazole alkanoic acids.
- •
1,5-, 1,4-, and 1,2-substituted imidazole derivatives evaluated as GAT inhibitors.
- •
One of the most potent mGAT3 inhibitors with pIC50 value of 5.13 ± 0.04.