MGAT5 alters the severity of multiple sclerosis
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- 作者：B. Brynedal ; J. Wojcik ; F. Esposito ; V. Debailleul ; J. Yaouanq ; F. Martinelli-Boneschi ; G. Edan ; G. Comi ; J. Hillert ; H. Abderrahim
- 关键词：Multiple sclerosis ; Severity ; MSSS ; Genetic association ; MGAT5
- 刊名：Journal of Neuroimmunology
- 出版年：2010
- 出版时间：30 March 2010
- 年：2010
- 卷：220
- 期：1-2
- 页码：120-124
- 全文大小：242 K
文摘
Multiple Sclerosis (MS) is a genetically complex immune mediated, demyelinating disease of the central nervous system. To date no genetic variants have been unambiguously linked to disease severity. We have conducted a genome wide screen, using Affymetrix Genechip® 500K technology, for severity in 1040 MS patients. Two markers within MGAT5, a gene coding for a glycosylation enzyme, were found to be significantly associated with outcome in the screening as well as in an independent population (combined p-values: 2.8 × 10− 6 and 1.5 × 10− 7).