Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals
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- 作者：A. David-Pereiraa ; b ; S. Pugaa ; b ; S. Gonç ; alvesa ; b ; D. Amorima ; b ; C. Silvaa ; b ; A. Pertovaarac ; A. Almeidaa ; b ; F. Pinto-Ribeiroa ; b ; filiparibeiro@ecsaude.uminho.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACC ; anterior cingulate cortex ; ARTH ; K/C-induced monoarthritis ; CHPG ; (RS)-2-chloro-5-hydroxyglycine (mGluR5 agonist) ; DHPG ; (S)-3 ; 5-dihydroxyphenylglycine (mGluR1/5 agonist) ; GLU ; glutamate ; i.p. ; intraperitoneal ; IL ; infralimbic cortex ; LIDO ; lidocaine ; LWT ; limb withdrawal threshold ; LY367385 ; (S)-(+)-α-amino-4-carboxy-2-methylbenzeneacetic acid (mGluR1 antagonist) ; mGluR ; metabotropic glutamate receptor ; MPEP ; 6-methyl-2-(phenylethynyl)pyridine (mGluR5 antagonist) ; MTEP ; 3-((2-methyl-1 ; 3-th
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：312
- 期：Complete
- 页码：108-119
- 全文大小：1610 K
文摘
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The infralimbic and prelimbic cortices tonically promote spinal antinociception.
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Glutamate in the infralimbic cortex enhances behavioral hyperalgesia.
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mGluR5 mediates infralimbic-induced hyperalgesia in control and monoarthritic rats.
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Selective inhibition of mGluR5 prevents IL-induced pronociception.