Differential involvement of mGluR1 and mGluR5 in memory reconsolidation and retrieval in a passive avoidance task in 1-day old chicks

详细信息    查看全文

• 作者：Katarzyna Gieros ; Anna Sobczuk ; Elzbieta Salinska ; ^{elas@cmdik.pan.pl}
• 关键词：mGluR1 ; mGluR5 ; Memory reconsolidation ; Retrieval ; Chicks
• 刊名：Neurobiology of Learning and Memory
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：97
• 期：1
• 页码：165-172
• 全文大小：394 K

文摘

Group I metabotropic glutamate receptors (mGluRs) are involved in memory formation. The Ca²⁺ signal derived from stimulation of IP₃ receptors (IP₃Rs) via mGluRs, initiates protein synthesis that is required for memory consolidation and reconsolidation. However it has been suggested that different mechanisms are triggered by mGluR1/5 activation in these two processes. It is also not clear whether the transient amnesia observed after blockade of group I mGluRs after a reminder, results from disturbance of memory reconsolidation or temporal impairment of recall.

The aim of this study was to examine more closely the role of mGluR1 in memory consolidation and reconsolidation and to detect differences in the participation of mGluR1 and mGluR5 in memory retrieval after initial training and after the remainder of the task.

Our results demonstrate, that in chicks performing a one-trial passive avoidance task, antagonists of mGluR1, mGluR5 and IP₃R significantly disturb memory consolidation and reconsolidation. Inhibition of mGluR5 and IP₃R also impairs memory recall, whereas mGluR1 do not seem to participate in this process.

The presented data suggest that activation of mGluR1 and mGluR5 is necessary for the correct course of memory consolidation and reconsolidation, whereas mGluR5 are additionally involved in retrieval processes dependent on Ca²⁺ release from IP₃ activated intracellular stores.