A sensitive LC-MS/MS method for analysis of pericyazine in presence of 7-hydroxypericyazine and pericyazine sulphoxide in human plasma and its application to a comparative bioequivalence study in Chinese healthy volunteers
刊名:Journal of Pharmaceutical and Biomedical Analysis
出版年:2017
出版时间:20 February 2017
年:2017
卷:135
期:Complete
页码:67-74
全文大小:1385 K
卷排序:135
文摘
Significant improvement in sensitivity for pericyazine (PCZ) determination. Investigation on the fragmentation pattern of PCZ and its major metabolites. Application of the LC–MS/MS method in a bioequivalence study for the first time. Firstly study the metabolism of PCZ in Chinese healthy volunteers. Using z-score transformation to normalize the AUC data for comparisons.