Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway
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- 作者：Shiv K. Singh1 ; Roberto Fiorelli1 ; Robert Kupp1 ; Sindhu Rajan1 ; Emily Szeto1 ; Costanza Lo Cascio1 ; Cecile L. Maire2 ; Yu Sun3 ; John A. Alberta3 ; Jennifer M. Eschbacher4 ; Keith L. Ligon2 ; Michael E. Berens5 ; Nader Sanai1 ; Shwetal Mehta1 ; shwetal.mehta@dignityhealth.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 July 2016
- 年：2016
- 卷：16
- 期：4
- 页码：950-966
- 全文大小：7638 K
文摘
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Glioma cells expressing unphosphorylated OLIG2 are highly invasive
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Unphosphorylated OLIG2 upregulates the TGF-β2 pathway and activates invasion genes
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Inhibition of the TGF-β pathway blocks OLIG2-mediated invasion
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Phospho-OLIG2 suppresses TGF-β2-mediated invasion