Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
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- 作者：Petra Bacher1 ; Frederik Heinrich2 ; Ulrik Stervbo3 ; 5 ; Mikalai Nienen3 ; Marco Vahldieck4 ; Christina Iwert5 ; Katrin Vogt5 ; Jutta Kollet4 ; Nina Babel3 ; 5 ; Birgit Sawitzki5 ; Carsten Schwarz6 ; Stefan Bereswill7 ; Markus M. Heimesaat7 ; Guido Heine8 ; Gabriele Gadermaier9 ; Claudia Asam9 ; Mario Assenmacher4 ; Olaf Kniemeyer10 ; Axel A. Brakhage10 ; Fá ; tima Ferreira9 ; Michael Wallner9 ; Margitta Worm8 ; Alexander Scheffold1 ; 2 ; 11 ; alexander.scheffold@charite.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：allergy ; regulatory T cell ; treg ; antigen-specific T cell ; birch pollen ; aspergillus fumigatus ; CD154 (CD40L) ; CD137 (4-1BB) ; tolerance ; allergen
- 刊名：Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：167
- 期：4
- 页码：1067-1078.e16
- 全文大小：7019 K
文摘
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A comprehensive characterization of antigen-specific human Treg responses
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Harmless aeroantigens are major tolerogenic Treg targets
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Allergic patients have intact Treg responses against aeroantigens
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Th2 responses escape Treg control due to divergent antigen specificities