A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells
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- 作者：Charlotte Huaa ; b ; 1 ; Rachel Audoa ; b ; 1 ; Nataliya Yeremenkoc ; Dominique Baetenc ; Michael Hahneb ; c ; Bernard Combea ; b ; Jacques Morela ; b ; Claire Daï ; ena ; b ; c-daien@chu-montpellier.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：APRIL ; B-lymphocytes ; Interleukin-10 ; Rheumatoid arthritis
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：64-72
- 全文大小：2015 K
文摘
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APRIL promotes IL-10 production of B-cells in healthy subjects and RA patients.
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BLyS does not promote IL-10 production of B-cells in healthy subjects and RA patients.
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IL-10 producing B cells express more TACI and less BAFF-R than IL-10–non-producing B cells.
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APRIL may be useful to restore IL-10 production of B-cells in RA patients.
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APRIL may be useful to restore B-cell regulatory functions in RA patients.