APRIL promotes IL-10 production of B-cells in healthy subjects and RA patients.
BLyS does not promote IL-10 production of B-cells in healthy subjects and RA patients.
IL-10 producing B cells express more TACI and less BAFF-R than IL-10–non-producing B cells.
APRIL may be useful to restore IL-10 production of B-cells in RA patients.
APRIL may be useful to restore B-cell regulatory functions in RA patients.