Cyclisation of aryl acetylides with isothiocyanates: new insight into an old reaction

详细信息    查看全文

• 作者：Harry Adams ; Hannah Hodson ; Michael J. Morris ; ^{M.Morris@sheffield.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Gareth A. Venting
• 关键词：Alkyne ; 3-Imino-1 ; 2-dithiole ; Isothiocyanate ; Heterocycle ; Thioamide
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：23 March 2016
• 年：2016
• 卷：57
• 期：12
• 页码：1328-1330
• 全文大小：816 K

文摘

The reaction of lithium phenylacetylide with phenyl isothiocyanate followed by the addition of ethanol produces a crystallographically-characterised heterocycle formed by the cyclisation of two molecules each of acetylene and isothiocyanate, and which is identical to the dimer of the acetylenic thioamide PhCbond; length of mdash" data-inlimg="/entities/tbnd" src="/sd/grey_pxl.gif" class="glyphImg imgLazyJSB">CC(bond; length as m-dash" data-inlimg="/entities/dbnd" src="/sd/grey_pxl.gif" class="glyphImg imgLazyJSB">S)NHPh, described almost a century ago.