Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca2+/NFAT Signaling
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- 作者：Beate Scholz1 ; 2 ; 9 ; 10 ; Claudia Korn1 ; 9 ; 11 ; Jessica Wojtarowicz1 ; 2 ; Carolin Mogler1 ; 3 ; Iris Augustin4 ; 5 ; Michael Boutros4 ; 5 ; Christof Niehrs6 ; 7 ; Hellmut G. Augustin1 ; 2 ; 8 ; augustin@angiogenese.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：angiogenesis ; vascular remodeling ; vascular pruning ; vascular regression ; WNT ; RSPO3 ; R-spondin ; non-canonical WNT pathway ; NFAT ; Moyamoya ; RNF213
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：11 January 2016
- 年：2016
- 卷：36
- 期：1
- 页码：79-93
- 全文大小：6647 K
文摘
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Rspo3 deletion from EC mimics the vessel regression phenotype of Evi-iECKO mice
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Rnf213, Usp18, and Trim30α are upregulated upon silencing of EC-derived Rspo3
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RNF213, USP18, and TRIM5α attenuate WNT/Calcium/NFAT signaling in vitro
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Blocking of NFAT activation in vivo by CsA phenocopies Rspo3 deletion from EC