The role of in vivo β-adrenergic stimulation on sweat production during exercise
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- 作者：Michael J. Buono ; Gabriela Gonzalez ; Shaun Guest ; Arabella Hare ; Travis Numan ; Brian Tabor ; Ailish White
- 关键词：Sweat ; Exercise ; Atropine ; Adrenergic stimulation ; Iontophoresis
- 刊名：Autonomic Neuroscience
- 出版年：2010
- 出版时间：24 June 2010
- 年：2010
- 卷：155
- 期：1-2
- 页码：91-93
- 全文大小：134 K
文摘
The purpose of the current study was to investigate the role of in vivo β-adrenergic stimulation on sweat production during exercise. To do this, atropine was used to block the cholinergic component of sweating, thus isolating any potential β-adrenergic response during exercise. The subjects for this study were 11 healthy volunteers. Atropine (1 % solution) and aminophylline (1 % solution) were administered to a 5 cm2 area of the flexor surface of one forearm via iontophoresis. The opposing arm underwent iontophoresis with a saline solution. Each subject then exercised at 75 % of their age-predicted maximum heart rate. During exercise, mean ± SD sweat rate in the control forearm was 0.63 ± 0.50 mg/cm2/min. There was no measurable sweat production in the arm pre-treated with atropine and aminophylline. Following exercise, iontophoresis of pilocarpine verified complete cholinergic blockade in the treated forearm. The results of the current study suggest that in vivo β-adrenergic stimulation alone is not sufficient to elicit sweating in exercising humans. Such data supports previous studies that have suggested that the role of β-adrenergic stimulation in vivo is to potentiate cholinergic sweating.