Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction
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- 作者：Xia Hu1 ; 6 ; Morayo G. Adebiyi1 ; 2 ; Jialie Luo3 ; Kaiqi Sun1 ; 2 ; Thanh-Thuy T. Le1 ; Yujin Zhang1 ; Hongyu Wu1 ; Shushan Zhao1 ; Harry Karmouty-Quintana1 ; Hong Liu1 ; 2 ; Aji Huang1 ; Yuan Edward Wen1 ; Oleg L. Zaika4 ; Mykola Mamenko4 ; Oleh M. Pochynyuk4 ; Rodney E. Kellems1 ; 2 ; Holger K. Eltzschig5 ; Michael R. Blackburn1 ; 2 ; Edgar T. Walters4 ; Dong Huang6 ; Hongzhen Hu3 ; Yang Xia1 ; 2 ; yang.xia@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：16
- 期：1
- 页码：106-119
- 全文大小：3441 K
文摘
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Adenosine (Ado) deaminase deficient mice displayed chronic pain
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Excess Ado signaling via ADORA2B promotes chronic pain in three distinct models
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ADORA2B activation induces immunoneuronal interaction and promotes chronic pain
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IL-6 trans-signaling underlies ADORA2B-induced prolonged hypersensitive nociception