Chemotherapy impedes in vitro microcirculation and promotes migration of leukemic cells with impact on metastasis
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- 作者：Sruti V. Prathivadhi-Bhayankarama ; Jianhao Ningb ; Michael Mimlitza ; Carolyn Taylora ; Erin Grossb ; Michael Nicholsa ; Jochen Guckc ; Andrew E. Ekpenyonga ; andrewekpenyong1@creighton.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cancer ; Cell mechanics ; Microfluidics ; Doxorubicin ; Daunorubicin ; Metastasis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：479
- 期：4
- 页码：841-846
- 全文大小：734 K
文摘
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Doxorubicin enhances migration of leukemic cancer cells before cell death.
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Doxorubicin and Daunorubicin stiffen and delay cells in mimicked microcirculation.
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Some cancer drugs cause changes in cell mechanics that lead to pro-metastatic effects.
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Cell mechanics becomes a new target for anti-metastatic drugs.