DNA Replication Is the Target for the Antibacterial Effects of Nonsteroidal Anti-Inflammatory Drugs
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- 作者：Zhou Yin1 ; Yao Wang1 ; Louise R. Whittell1 ; Slobodan Jergic1 ; Michael Liu2 ; Elizabeth Harry2 ; Nicholas E. Dixon1 ; Michael J. Kelso1 ; Jennifer L. Beck1 ; Aaron J. Oakley1 ; aarono@uow.edu.au" class="auth_mail
- 刊名：Chemistry & Biology
- 出版年：24 April 2014
- 年：2014
- 卷：21
- 期：4
- 页码：481-487
- 全文大小：1543 K
文摘
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Some NSAIDs with in vitro antibacterial activity inhibit the E. coli sliding clamp
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These NSAIDs bind to a pocket essential for the sliding clamp’s binding partners
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NSAIDs inhibit sliding-clamp-dependent DNA replication