Therapeutic effects of stress-programmed lymphocytes transferred to chronically stressed mice
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- 作者：Rachel B. Scheinert ; Mitra H. Haeri ; Michael L. Lehmann ; Miles Herkenham ; herkenh@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：BrdU ; ((+)-5-bromo-2-deoxyuridine) ; GFP ; green fluorescent protein ; HC ; Home-cage ; L/D ; light/dark ; OFT ; open field test ; Rag2 ; recombination activating gene 2 ; SD ; social defeat ; TST ; tail suspension test ; UBC ; human ubiquitin C
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：3 October 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：1-7
- 全文大小：863 K
文摘
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Rag2−/− mice lacking an adaptive immune system have normal affect and hippocampal cell proliferation.
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Chronic restraint stress creates an anxious and depressed state in both Rag2−/− and control mice.
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Transfer of lymphocytes from stressed mice into stressed Rag2−/− mice restores normal affect.
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Transferred lymphocytes populate lymphoid organs, choroid plexus, and meninges.