Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes

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• 作者：Kortenjann ; Monika ; Wehrle ; Christian ; Nehls ; Michael C. ; Boehm ; Thomas
• 关键词：Nemo-like kinase ; Genomes ; MAP ; mitogen activated protein ; TCF ; T cell factor ; BAC ; bacterial artificial chromosome
• 刊名：Gene
• 出版年：2001
• 出版时间：October 31, 2001
• 年：2001
• 卷：278
• 期：1-2
• 页码：161-165
• 全文大小：174 K

文摘

The nemo-like kinase (Nlk) connects the MAP kinase and Wnt signalling pathways. We have found that invertebrate (Caenorhabditis elegans, Drosophila melanogaster) and mammalian genomes (Mus musculus and Homo sapiens) each contain only a single functional Nlk gene. The mouse genome also harbours a transcriptionally silent processed Nlk pseudogene residing on chromosome 2. Thus, while genes encoding upstream (such as Wnts and frizzelds) and downstream (such as TCF/LEF) components of the Wnt signalling pathway have been extensively diversified during evolution, genes encoding components of the common core of the connecting signalling structure (such as β-catenin, GSKβ and Nlk) have been maintained in single copies.