Characterization of aldehyde dehydrogenase 1 high ovarian cancer cells: Towards targeted stem cell therapy
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- 作者：Allison C. Sharrowa ; 1 ; acsharrow@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Brandy Perkinsb ; bperkin6@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Michael I. Collectorb ; Wayne Yub ; Wyu8@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Brian W. Simonsc ; bsimons3@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Richard J. Jonesb ; rjjones@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ovarian cancer ; Cancer stem cells ; Aldehyde dehydrogenase 1 ; Stem cell-targeted therapy
- 刊名：Gynecologic Oncology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：142
- 期：2
- 页码：341-348
- 全文大小：1241 K
文摘
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ALDHhigh ovarian cancer cells phenotypically resemble cancer stem cells (CSCs).
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Based on gene expression ALDHhigh and ALDHlow cells are biologically distinct.
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Other reported ovarian CSC markers do not consistently identify ALDHhigh cells.
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Potential therapeutic targets include: mTOR signaling, her-2/neu, CD47 and FGFR3.