Blood Pressure and LV Remodeling Among American-Style Football Players

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• 作者：Jeffrey Lin ; MD^a ; Francis Wang ; MD^b ; Rory B. Weiner ; MD^a ; ^b ; James R. DeLuca ; BA^a ; Meagan M. Wasfy ; MD^a ; Brant Berkstresser ; MS ; ATC^b ; Gregory D. Lewis ; MD^a ; Adolph M. Hutter Jr. ; MD^a ; Michael H. Picard ; MD^a ; Aaron L. Baggish ; MD^a ; ^b ; ^{abaggish@partners.org}
• 关键词：athlete&rsquo ; s heart syndrome ; hypertension ; left ventricular function ; left ventricular hypertrophy
• 刊名：JACC: Cardiovascular Imaging
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：12
• 页码：1367-1376
• 全文大小：427 K
• 卷排序：9

文摘

This study sought to determine the relationships among American-style football (ASF) participation, acquired left ventricular (LV) hypertrophy, and LV systolic function as assessed using contemporary echocardiographic parameters.BackgroundParticipation in ASF has been associated with development of hypertension and LV hypertrophy. To what degree these processes impact LV function is unknown.MethodsThis was a prospective, longitudinal cohort study evaluating National Collegiate Athletic Association Division I football athletes stratified by field position (linemen: n = 30; vs. nonlinemen, n = 57) before and after a single competitive season, using transthoracic echocardiography. LV systolic function was measured using complementary parameters of global longitudinal strain (GLS) (using 2-dimensional speckle-tracking) and ejection fraction (EF) (2-dimensional biplane).ResultsASF participation was associated with field position-specific increases in systolic blood pressure (SBP) (a Δ SBP of 10 ± 8 mm Hg in linemen vs. a Δ SBP of 3 ± 7 mm Hg in nonlinemen; p < 0.001) and an overall increase in incident LV hypertrophy (pre-season = 8% vs. post-season = 25%, p < 0.05). Linemen who developed LV hypertrophy had concentric geometry (9 of 11 [82%]) with decreased GLS (Δ = −1.1%; p < 0.001), whereas nonlinemen demonstrated eccentric LV hypertrophy (8 of 10 [80%]) with increased GLS (Δ = +1.4%; p < 0.001). In contrast, LV ejection fraction in the total cohort, stratified by field position, was not significantly affected by ASF participation. Among the total cohort, lineman field position, post-season weight, SBP, average LV wall thickness, and relative wall thickness were all independent predictors of post-season GLS.ConclusionsASF participation at a lineman field position may lead to a form of sport-related myocardial remodeling that is pathologic rather than adaptive. Future study will be required to determine if targeted efforts to control blood pressure, minimize weight gain, and to include an element of aerobic conditioning in this subset of athletes may attenuate this process and translate into tangible downstream health benefits.