Iron deficiency in children with HIV-associated anaemia: a systematic review and meta-analysis

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• 作者：Michael O. Esan ; Femkje A.M. Jonker ; Michael Boele van Hensbroek ; Job C.J. Calis ; Kamija S. Phiri
• 关键词：HIV ; Iron deficiency ; Children ; Meta-analysis ; Systematic review
• 刊名：Transactions of the Royal Society of Tropical Medicine and Hygiene
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：106
• 期：10
• 页码：579-587
• 全文大小：400 K

文摘

We conducted a systematic review and meta-analysis to determine the prevalence of iron deficiency in HIV-infected children from high- and low-income settings and compared it with that of HIV-uninfected controls. We searched five major databases for primary studies reporting on anaemia and iron markers in HIV-infected children. A pooled analysis was done using random-effects models, with Forest plots and heterogeneity test estimates provided. Fifteen articles (2778 children) met the inclusion criteria. In the pooled analysis, mean overall prevalence of iron deficiency in HIV-infected children was 34 % (95 % CI 19-50 % ). Prevalence rates were similar in high-income (31 % ; 95 % CI 2-61 % ) and low-income settings (36 % ; 95 % CI 17-54 % ) (p=0.14). Studies that included a HIV-uninfected control population (n=4) were only available from low-income settings and showed less iron deficiency in HIV-infected children (28 % ) than in HIV-uninfected children (43 % ); OR 0.50 (0.27-0.94); p=0.03. The findings suggest that HIV-infected children are less likely to be iron deficient when compared with HIV-uninfected children. Possible explanations for this include HIV-induced haematosuppression and associated hypoferraemia, with adequate iron stores. Nevertheless iron deficiency is a common co-morbidity in HIV. Studies are needed to determine the role of iron deficiency in HIV-associated anaemia and the effects of iron supplementation in this population.