Solitary Sporadic Cerebral Cavernous Malformations: Risk Factors of First or Recurrent Symptomatic Hemorrhage and Associated Functional Impairment

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• 作者：Philipp Dammann¹ ; ^{philipp.dammann@uk-essen.de" class="auth_mail" title="E-mail the corresponding author} ; Ramazan Jabbarli¹ ; Paula Wittek¹ ; Marvin Darkwah Oppong¹ ; Andreas Kneist¹ ; Yuan Zhu¹ ; Karsten Wrede¹ ; Oliver Mü ; ller¹ ; Michael Forsting² ; Ulrich Sure¹
• 关键词：Cerebral cavernous malformation ; Functional impairment ; Intracerebral hemorrhage ; Natural history
• 刊名：World Neurosurgery
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：91
• 期：Complete
• 页码：73-80
• 全文大小：4019 K

文摘

To quantify the risk of a first or recurrent hemorrhage and the associated functional impairment in patients with sporadic solitary cerebral cavernous malformations (CCMs) and to investigate the potential risk factors.

Methods

We undertook an observational study (n = 199) of consecutive patients with the diagnosis of a single, sporadic CCM using clinical and magnetic resonance imaging follow-up to identify prospective hemorrhage events and associated functional impairment. We calculated the annual hemorrhage risk rates, calculated cumulative risks, and performed uni- and multivariate analysis to assess outcome predictors.

Results

There were 199 adults identified, and 712.5 person years of follow-up were analyzed. Overall annual rates of hemorrhage were 6.03%, 11.95%, and 1.03% in the complete cohort, in those presenting with previous hemorrhage, and in those without, respectively. The 5-year risk of hemorrhage was higher in those presenting with previous hemorrhage than those without (40.9%; 95% confidence interval [CI], 31.78–50.73 vs. 8.6%; 95% CI, 3.97–16.95; P < 0.0001) and in those with a brainstem CCM compared with nonbrainstem CCM (51.6%; 95% CI, 37.61–65.46 vs. 17.1%; 95% CI, 4.55–32.04; P < 0.0001). In the multivariate analysis, previous hemorrhage (odds ratio, 7.18; 95% CI, 1.8–28.11; P = 0.005), age less than 45 years (odds ratio, 2.61; 95% CI, 1.03–6.61; P = 0.042), and brainstem location (odds ratio, 7.44; 95% CI, 2.09–26.50; P = 0.002) increased the risk of hemorrhage. Of the patients, 30% showed a moderate or severe disability associated with a CCM hemorrhage (5-year risk of severe hemorrhage, 8.9%; 95% CI, 5.50–13.99).

Conclusions

This study provides an estimate of symptomatic hemorrhage risk and the associated disability in patients with sporadic solitary CCM and an investigation of risk factors.