Synthesis and antiviral evaluation of thieno[3,4-d

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• 作者：Marie Hamann ; Claire Pierra ; Jean-Pierre Sommadossi ; Chiara Musiu ; Luana Vargiu ; Michel Liuzzi ; Richard Storer ; Gilles Gosselin
• 关键词：HIV-1 ; NRTI ; 2′ ; 3′ ; -Dideoxy C-nucleoside analogues ; 7 ; 9-Dideaza-8-thiapurine series ; Synthesis ; Antiviral evaluation
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2009
• 出版时间：15 March 2009
• 年：2009
• 卷：17
• 期：6
• 页码：2321-2326
• 全文大小：358 K

文摘

Several thieno[3,4-d]pyrimidine derivatives, including four hitherto unknown 2′,3′-dideoxy- and 2′,3′-dideoxy-2′,3′-didehydro-C-nucleoside analogues of adenosine and inosine have been synthesized. When evaluated in cell culture experiments against human immunodeficiency virus, none of the tested compounds exhibited any significant antiviral effect, while two of them showed some cytotoxicity.