Intramolecular alkynylogous Mukaiyama aldol type reaction mediated by TBSOTf/NEt₃

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• 作者：Laurence Miesch ; Vincent Rietsch ; Tania Welsch ; Michel Miesch
• 关键词：Allenoate ; Lewis acids ; Cascade ; Aldol ; Alkynylogous
• 刊名：Tetrahedron Letters
• 出版年：2008
• 出版时间：18 August 2008
• 年：2008
• 卷：49
• 期：34
• 页码：5053-5055
• 全文大小：179 K

文摘

The treatment of propargylic esters tethered to bicyclo[3.2.0]heptanone, 2-methylindanone, 2-methyltetralone, or 2-methylsuberone led to fused tricyclic allenoates by an intramolecular alkynylogous Mukaiyama aldol type reaction promoted by TBSOTf/NEt₃, the key intermediates being silylalkynylketene acetals.