The meaning of tissue and serum HCV RNA quantitation in hepatitis C recurrence after liver transplantation: A retrospective study

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• 作者：Francesco Vasuri^a ; Maria Cristina Morelli^b ; Elisa Gruppioni^a ; Michelangelo Fiorentino^a ; Giorgio Ercolani^b ; Matteo Cescon^b ; Antonio Daniele Pinna^b ; Walter Franco Grigioni^a ; Antonia D&rsquo ; Errico-Grigioni^a ; ^{derrico@aosp.bo.it}
• 关键词：Hepatitis C virus ; HCV recurrence ; OLT ; Polymerase chain reaction
• 刊名：Digestive and Liver Disease
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：45
• 期：6
• 页码：505-509
• 全文大小：341 K

文摘

Background

While the role of serum HCV RNA quantitation in hepatitis C virus recurrence after liver transplantation is well established, the meaning of HCV RNA tissue quantitation is largely unclear, and no correlations with recipient outcome have been investigated yet.

Aims

To assess the predictive value, and a possible prognostic role, of tissue and serum HCV RNA in first post-transplant biopsies.

Methods

We retrospectively reviewed the first post-transplant biopsies of 83 recipients. Tissue and serum HCV RNA was quantitated by RT-PCR, and compared with serum, clinical and histological data.

Results

HCV RNA quantitation allowed us to categorise recipients into three different risk groups: (1) tissue HCV RNA ¡Ü 1.5 IU/ng with any serum HCV RNA; (2) tissue HCV RNA > 1.5 IU/ng and serum HCV RNA < 40 ¡Á 10⁶ copies/mL; (3) tissue HCV RNA > 1.5 IU/ng and serum HCV RNA ¡Ý 40 ¡Á 10⁶ copies/mL. Hepatitis C virus recurrence rates in the three groups were 68 % , 91 % and 100 % (P = 0.004); hepatitis C virus-related mortality was 0 % , 14 % and 45 % respectively (P < 0.001).

Conclusions

This preliminary study on serum and tissue HCV RNA quantitation allows recipient ¡°stratification¡± in prognostic groups, which could be applicable in the future for timely antiviral treatment and/or immunosuppression modulation.