[¹²³I]FP-CIT single photon emission computed tomography findings in drug-induced Parkinsonism

详细信息    查看全文

• 作者：Michele Tinazzi ; Andrea Cipriani ; Angela Matinella ; Antonino Cannas ; Paolo Solla ; Aless ; ra Nicoletti ; Mario Zappia ; Letterio Morgante ; Francesca Morgante ; Claudio Pacchetti ; Massimo Sciarretta ; Carlo Dallocchio ; Simone Rossi ; Maria Malentacchi ; Roberto Ceravolo ; Daniela Frosini ; Stelvio Sestini ; Tommaso Bovi ; Corrado Barbui
• 关键词：Schizophrenia ; Parkinsonism ; [123I]FP-CIT SPECT ; Antipsychotics ; Dopamine receptors
• 刊名：Schizophrenia Research
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：139
• 期：1-3
• 页码：40-45
• 全文大小：212 K

文摘

Drug-induced parkinsonism (DIP) in patients treated with antipsychotic drugs is considered a form of post-synaptic parkinsonism, caused by D2-receptor blockade. Recent studies, however, carried out on small and heterogeneous patient samples, have shown that DIP may be associated with [¹²³I]FP-CIT single photon emission computed tomography (SPECT) abnormalities, which are markers of dopamine nigrostriatal terminal defect.

In the present study, outpatients fulfilling the DSM-IV criteria for schizophrenia and treated with antipsychotics for at least 6 months, were enrolled in order to estimate the prevalence of DIP and, among patients with DIP, the prevalence of [¹²³I]FP-CIT SPECT abnormalities. Socio-demographic and clinical variables associated with the presence of DIP and SPECT abnormalities were also assessed.

DIP was diagnosed in 149 out of 448 patients with schizophrenia (33 % ). Age, use of long-acting antipsychotics and a positive family history of parkinsonism were the only demographic variables significantly associated with the development of DIP. Neuroimaging abnormalities were found in 41 of 97 patients who agreed to undergo [¹²³I]FP-CIT SPECT (42 % ). Only age differentiated this group of patients from those with normal imaging.

These preliminary findings suggest that D2-receptor blockade may coexist with a dopamine nigrostriatal terminal defect, as assessed by [¹²³I]FP-CIT SPECT abnormalities, in a relevant proportion of DIP patients. Longitudinal studies should be designed with the aim of improving our understanding of the mechanisms of pre-synaptic abnormalities in DIP patients and identifying specific treatment strategies.