Motor cortex reorganisation in Parkinson’s disease
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- 作者：Gary W. Thickbroom ; Michelle L. Byrnes ; Susan Walters ; Rick Stell ; Frank L. Mastaglia
- 关键词：Parkinson’ ; s disease ; TMS mapping ; Cortical reorganisation
- 刊名：Journal of Clinical Neuroscience
- 出版年：2006
- 出版时间：July 2006
- 年：2006
- 卷：13
- 期：6
- 页码：639-642
- 全文大小：138 K
文摘
Transcranial magnetic stimulation mapping of the motor cortical projection to the hand was performed in a group of patients with Parkinson’s disease (PD) of variable duration to determine whether there is evidence of cortical reorganisation. Map shifts were found in the majority of PD cases (12/15), in untreated early cases as well as treated cases of longer duration, and there was a correlation between inter-side difference in the severity of PD symptoms (Unified Parkinson’s Disease Rating Scale) and interhemispheric map displacement (r = 0.60; P = 0.018). These findings indicate that there is reorganisation of the corticomotor representation of the hand in PD, even at a relatively early stage of the disease, and suggest a dynamic process of reorganisation in the motor cortex due to an increase in the pallidal inhibitory inputs to the thalamo-cortical projections.