Prenatal morphine exposure alters ovarian steroid hormonal regulation of seizure susceptibility

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• 作者：Velí ; &scaron ; ek ; Libor ; Velí ; &scaron ; ková ; Jana ; Moshé ; Solomon L. ; et. al.
• 关键词：Estrogen ; Progesterone ; Flurothyl ; Low magnesium ; Convulsion ; Forebrain ; Brainstem ; Entorhinal cortex
• 刊名：Brain Research
• 出版年：1998
• 出版时间：June 15, 1998
• 年：1998
• 卷：796
• 期：1-2
• 页码：247-256
• 全文大小：1.03 M

文摘

The present study examined the ovarian hormonal regulation of seizure susceptibility in prenatally morphine- and saline-exposed adult female rats in the flurothyl seizure model in vivo, and in low-magnesium-induced epileptiform activity in brain slices, in vitro. All females were ovariohysterectomized (OVX); some received either estrogen (E) or progesterone (P) replacement, while others were injected with E+P sequentially. In prenatally saline-treated control females, there was an increase in the flurothyl-induced clonic seizure threshold (anticonvulsant effect) in the presence of both hormones (E+P) compared to OVX controls. In morphine-exposed females, there was an increase in the flurothyl-induced clonic seizure threshold after an E injection alone while there was a reduced tonic–clonic seizure threshold in the presence of both hormones (E+P) compared to the hormone treatment-matched group of saline-exposed females. In control females, in low magnesium medium in vitro, the development of two types of epileptiform activity (seizure-like events and status of short discharges) was not affected by the different hormonal conditions. However, prenatal morphine exposure suppressed the development of both types of epileptiform activity in the E-injected females compared to the E-injected, control females. The present data demonstrate that the anticonvulsant effects of P on seizure susceptibility requires the presence of E. Furthermore, prenatal morphine exposure alters ovarian steroid hormone-regulated seizure susceptibility. Publisher: Elsevier Science Language of Publication: English Item Identifier: S0006-8993(98)00367-9 Publication Type: Article ISSN: 0006-8993 Cited by:

1. Schindler, Cheryl J.; Slamberova, Romana; Vathy, Ilona,""Prenatal morphine exposure decreases susceptibility of adult male rat offspring to bicuculline seizures""Brain Research2001pp. 305-309
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2. Slamberova, Romana; Schindler, Cheryl J.; Pometlova, Marie; Urkuti, Claudia; Purow-Sokol, Jennifer A.; Vathy, Ilona,""Prenatal morphine exposure differentially alters learning and memory in male and female rats""Physiology and Behavior2001pp. 93-103
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3. Slamberova, Romana; Rimanoczy, Agnes; Riley, Michelle A.; Schindler, Cheryl J.; Vathy, Ilona,""Mu-opioid receptors in seizure-controlling brain structures are altered by prenatal morphine exposure and by male and female gonadal steroids in adult rats""Brain Research Bulletin2002pp. 391-400
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4. Slamberova, Romana; Schindler, Cheryl J.; Vathy, Ilona,""Impact of maternal morphine and saline injections on behavioral responses to a cold water stressor in adult male and female progeny""Physiology and Behavior2002pp. 723-732
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5. Schindler, C.J.; Slamberova, R.; Vathy, I.,""Bicuculline seizure susceptibility and nigral GABA_A a₁ receptor mRNA is altered in adult prenatally morphine-exposed females¹""Psychoneuroendocrinology2003pp. 348-363
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6. Slamberova, Romana; Vathy, Ilona,""Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats""Pharmacology Biochemistry and Behavior2000pp. 501-505
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Footnotes:

1. Note: Data in this paper are from a thesis to be submitted in partial fulfillment of the requirements for the Degree of Doctor of Philosophy in the Sue Golding Graduate Division of Medical Sciences, Albert Einstein College of Medicine, Yeshiva University.