ID: 49: Bat type I IFN: Contraction of the genetic locus and constitutive expression of IFN伪

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• 作者：Peng Zhou¹ ; ² ; ; Victoria Boyd¹ ; Mary Tachedjian¹ ; Jie Cui² ; Ina Smith¹ ; Chris Cowled¹ ; James Wynne¹ ; Linfa Wang¹ ; ² ; Michelle Baker¹
• 刊名：Cytokine
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：76
• 期：1
• 页码：73
• 全文大小：43 K

文摘

Bats are known to harbour a number of emerging and re-emerging zoonotic viruses, many of which are highly pathogenic in other mammals (MERS, Ebola among others) but result in no clinical symptoms in bats. The ability of bats to coexist with viruses may be the result of rapid control of viral replication early in the immune response. To determine the role of IFNs in the ability of bats to coexist with viruses we sequenced the type I IFN locus of the Australian black flying fox, Pteropus alecto, providing the first map of the IFN region of any bat. Our results reveal a highly contracted type I IFN family consisting of only ten IFNs, including three functional IFN伪$\mathrm{伪}$ loci. Furthermore, the three IFN伪$\mathrm{伪}$s are constitutively expressed in unstimulated bat tissues and cells and their expression is unaffected by viral infection. Analysis of the putative promoter regions of the bat IFN伪$\mathrm{伪}$ genes has revealed that the three IRF binding modules are different in the identified bat IFN伪$\mathrm{伪}$, which may contribute to its constitutive expression. These discoveries are consistent with differences in the IFN伪$\mathrm{伪}$ system of bats compared with other mammals and may have important implications for the role of type I IFNs in the ability of bats to coexist with viruses.