Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites
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- 作者：Jurgen R. Haanstraa ; Eglys B. Gonzá ; lez-Marcanob ; Melisa Gualdró ; n-Ló ; pezc ; Paul A.M. Michelsb ; d ; paul.michels@ed.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATG ; autophagy ; BSF ; bloodstream-form ; CAA ; citrate and/or cis-aconitate ; FP ; fluorescent protein ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; GFP ; green-fluorescent protein ; HAT ; human African trypanosomiasis ; HXK ; hexokinase ; LS ; long-slender ; PAD ; protein associated with differentiation ; PCF ; procyclic form ; PEX ; peroxin ; PFK ; phosphofructokinase ; PGAM ; phosphoglycerate mutase ; PGK ; phosphoglycerate kinase ; PMP ; peroxisomal membrane protein ; PTS ; peroxisomal-targeting signal ; PYK ; pyruva
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：1863
- 期：5
- 页码：1038-1048
- 全文大小：1441 K
文摘
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Glycosomes are specialized peroxisomes in protists of the taxon Kinetoplastea.
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Glycosomes compartmentalize enzymes of glycolysis and some other metabolic processes.
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Compartmentation compensates for a lack of feedback regulation of glycolytic enzymes.
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Glycosome turnover and dynamics play important roles in remodelling of metabolism.
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A glycosome-targeted phosphatase participates in lifecycle differentiation signalling.