Designing ageing conditions in tumour microenvironment—A new possible modality for cancer treatment

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• 作者：Judith Leibovici ; Orit Itzhaki ; Tatiana Kaptzan ; Ehud Skutelsky ; Judith Sinai ; Moshe Michowitz ; Raida Asfur ; Annette Siegal ; Monica Huszar ; Ginnette Schiby
• 关键词：Cancer ; Ageing ; Age-adjusted therapy
• 刊名：Mechanisms of Ageing and Development
• 出版年：2009
• 出版时间：January-February 2009
• 年：2009
• 卷：130
• 期：1-2
• 页码：76-85
• 全文大小：2383 K

文摘

While tumour incidence is known to augment with age, paradoxically tumour growth and metastasis were often found to proceed at a slower rate at late ages. This age-related biological behaviour of tumours actually imposes a differential therapeutic approach to the old cancer patient. Several mechanisms of the age-related reduced tumour progression have been demonstrated: decreased tumour cell proliferation, increased apoptotic cell death, decreased angiogenesis and anti-tumoural immune response changes. We postulated that it might be possible to design age-adjusted treatment modalities based on the mechanisms responsible for the reduced tumour progression rate in the aged. Based on these mechanisms, we compared the effect of different treatments (apoptosis-inducing agents, Hydrocortisone and Adriamycin, anti-angiogenic agent, TNP-470, and immunomodulators-Levamisole and BCG) on two experimental tumours (B16 melanoma and AKR lymphoma) growing in young and old mice. Most treatments showed, in both tumours, a higher inhibitory effect on tumours growing in old mice than on those developing in young ones, to our knowledge, a feature not described before for anti-tumoural agents. We suggest that designing ageing conditions in tumours of young patients might possibly alleviate neoplastic aggressiveness in these patients as well.