Analysis of genomic responses in a rat lung model treated with a humidifier sterilizer containing polyhexamethyleneguanidine phosphate

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• 作者：Min-Seok Kim^a ; ¹ ; Seok Won Jeong^b ; ¹ ; Seong-Jin Choi^a ; Jin-Young Han^a ; ^d ; Sung-Hwan Kim^a ; Seokjoo Yoon^c ; ^d ; Jung-Hwa Oh^c ; ^d ; Kyuhong Lee^a ; ^d ; ^{khlee@kitox.re.kr} ; ^{khleekit@gmail.com}
• 关键词：Humidifier disinfectant ; PHMG phosphate ; Pulmonary disease ; DNA microarray ; Biomarkers
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：268
• 期：Complete
• 页码：36-43
• 全文大小：953 K
• 卷排序：268

文摘

We investigated the geno-toxicological effects of PHMG phosphate in the rat lung using a DNA microarray. PHMG phosphate altered expression of genes involved in the urea cycle, inflammation, and oxidative stress. 21 genes were induced and 4 genes were repressed in response to PHMG phosphate in a timedependent manner.