The first interdisciplinary experiments at the IMP high energy microbeam

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• 作者：Guanghua Du^a ; ; Jinlong Guo^a ; Ruqun Wu^a ; Na Guo^a ; Wenjing Liu^a ; Fei Ye^a ; Lina Sheng^a ; Qiang Li^a ; Huiyun Li^b
• 关键词：High energy microbeam ; Bystander effect ; Microbeam therapy ; RSA ; Fault injection attack
• 刊名：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
• 出版年：2015
• 出版时间：1 April 2015
• 年：2015
• 卷：348
• 期：Complete
• 页码：18-22
• 全文大小：1107 K

文摘

The high energy beam of tens to hundred MeV/u ions possesses mm-to-cm penetration depth in materials and can be easily extracted into air without significant energy loss and beam scattering. Combination of high energy ions and microbeam technology facilitates the microprobe application to many practical studies in large scale samples. The IMP heavy ion microbeam facility has recently been integrated with microscopic positioning and targeting irradiation system. This paper introduced the first interdisciplinary experiments performed at the IMP microbeam facility using the beam of 80.5 MeV/u carbon ions. Bystander effect induction via medium transferring was not found in the micro-irradiation study using HeLa cells. The mouse irradiation experiment demonstrated that carbon irradiation of 10 Gy dose to its tuberomammillary nucleus did not impair the sleep nerve system. The fault injection attack on RSA (Rivest–Shamir–Adleman) decryption proved that the commercial field-programmable gate array chip is vulnerable in single event effect to low linear-energy-transfer carbon irradiation, and the attack can cause the leakage of RSA private key. This work demonstrates the potential of high energy microbeam in its application to biology, biomedical, radiation hardness, and information security studies.