Rethinking Diet to Aid Human-Microbe Symbiosis

详细信息    查看全文

• 作者：Muriel Derrien¹ ; ^{muriel.derrien@danone.com} ; Patrick Veiga¹ ; ^{patrick.veiga@danone.com}
• 关键词：gut microbiota ; prevention ; diet ; probiotics ; stratification ; responders
• 刊名：Trends in Microbiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：100-112
• 全文大小：2182 K
• 卷排序：25

文摘

The spread of the Western lifestyle has been accompanied by microbial changes thought to underlie the emergence of chronic, nontransmissible, immune-related diseases. The past decade has seen the unprecedented development of therapies for ‘replenishing’ the microbiota of sick individuals. However, functional and ecological solutions helping the host and the gut microbiota to cope with the ecological stressors of modern life are still lacking. In this review, we discuss how recent advances in gut microbiome science are leading to the identification of microbe-derived and health-relevant metabolites. These molecules will guide the selection of the next-generation of probiotics and dietary recommendations, which should also take the resident gut microbiota into account, to optimise efficacy. These solutions for maintaining a well-functioning gut ecosystem and promoting good health should be customised, palatable, and as widely accessible as possible.