Kynurenine pathway metabolism and the microbiota-gut-brain axis

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• 作者：P.J. Kennedy^a ; ^b ; J.F. Cryan^a ; ^c ; T.G. Dinan^a ; ^b ; G. Clarke^a ; ^b ; ^{g.clarke@ucc.ie}
• 关键词：Tryptophan ; Kynurenine ; Stress ; Immune system ; Microbiota-gut-brain-axis ; Behaviour
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：112
• 期：part_PB
• 页码：399-412
• 全文大小：1450 K
• 卷排序：112

文摘

Brain function and behaviour are under substantial microbial control. Kynurenine pathway metabolism is critical in a range of CNS and GI functions. Gut microbiota may regulate kynurenine pathway metabolism via numerous mechanisms. The gut microbiota may be targeted to modulate kynurenine pathway metabolism. Microbial-modulated kynurenine metabolism may prove beneficial for CNS function.