Selective cytotoxicity of microcystins LR, LW and LF in rat astrocytes

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• 作者：Klara Bulc Rozman^a ; ^{klara.bulc@rozman.si} ; Damijana Mojca Jurič^b ; ^{damijana-mojca.juric@mf.uni-lj.si} ; Du&scaron ; an &Scaron ; uput^a ; ^{dusan.suput@mf.uni-lj.si}
• 关键词：Microcystin ; Cytotoxicity ; Astrocytes ; Oatp ; Cytoskeleton
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：265
• 期：Complete
• 页码：1-8
• 全文大小：1736 K
• 卷排序：265

文摘

MC-LF and MC-LW, but not MC-LR, are toxic to astrocytes. MC-LW and MC-LF induce apoptosis of rat cortical astrocytes. MC-LW and MC-LF intoxication induce GFAP, actin and tubulin network degradation. Rat cortical astrocytes express Oatp1a4, Oatp1c1 and Oatp1a5, but not Oatp1b2.