Lineage Reprogramming: A Promising Road for Pancreatic β Cell Regeneration

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• 作者：Rui Wei¹ ; Tianpei Hong¹ ; ^{tpho66@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：cell reprogramming ; cell replacement therapy ; transdifferentiation ; pancreatic β cells ; diabetes mellitus
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：27
• 期：3
• 页码：163-176
• 全文大小：2200 K

文摘

Cell replacement therapy is a promising method to restore pancreatic β cell function and cure diabetes. Distantly related cells (fibroblasts, keratinocytes, and muscle cells) and developmentally related cells (hepatocytes, gastrointestinal, and pancreatic exocrine cells) have been successfully reprogrammed into β cells in vitro and in vivo. However, while some reprogrammed β cells bear similarities to bona fide β cells, others do not develop into fully functional β cells. Here we review various strategies currently used for β cell reprogramming, including ectopic expression of specific transcription factors associated with islet development, repression of maintenance factors of host cells, regulation of epigenetic modifications, and microenvironmental changes. Development of simple and efficient reprogramming methods is a key priority for developing fully functional β cells suitable for cell replacement therapy.