With the assistance of the polymer microfiber, we propose a simple approach to fabricating silica-based optical microfiber knot resonators (MKRs) in this paper. A pre-fabricated knot ring made of the polymer microfiber can be readily driven to the silica microfiber owing to the intensive van der Waals and the electrostatic forces between the polymer and the silica microfibers. The fabrication process is introduced in detail. Several kinds of MKRs are fabricated and their optical performances are demonstrated accordingly.