Platelet CD40L induces activation of astrocytes and microglia in hypertension

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• 作者：Shahnawaz Ali Bhat^a ; Ruby Goel^a ; Rakesh Shukla^a ; Kashif Hanif^a ; ^b ; ^{k_hanif@cdri.res.in}
• 关键词：CD40L ; Astrocytes ; Microglia ; Neuroinflammation ; Neurodegeneration ; Adhesion molecules
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：173-189
• 全文大小：6406 K
• 卷排序：59

文摘

HTN increases the expression of adhesion molecules and deposition of platelets in brain. Platelet CD40L mediates activation of astrocytes and microglia during hypertension. CD40L activates NFкB and MAPK inflammatory signaling in astrocytes and microglia. Inhibition of platelet activation or CD40L axis prevents glial activation and neuroinflammation.