Interactions among biotic and abiotic factors affect the reliability of tungsten microneedles puncturing in vitro and in vivo peripheral nerves: A hybrid computational approach
详细信息 查看全文
- 作者：Pier Nicola Sergia ; p.sergi@sssup.it" class="auth_mail" title="E-mail the corresponding author ; Winnie Jensenb ; Ken Yoshidac
- 关键词：In vivo reliability of tungsten microneedles ; Biotic and abiotic factors ; Peripheral nerves ; Local interactions ; Adiabatic invariants
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：1089-1099
- 全文大小：1425 K
文摘
- •
We provide phenomenological Finite Element (FE) models of peripheral nerves to study the interactions with W microneedles
- •
We provide a general interaction-based approach to model the reliability of slender microneedles
- •
We evaluate the reliability of W microneedels to puncture in vivo nerves
- •
We provide a novel synergistic hybrid approach (theory + simulations) involving interactions among biotic and abiotic factors
- •
We validate the hybrid approach by using experimental data from literature