Nanosilica based electrochemical biosensor: A novel approach for the detection of platelet-derived microparticles

详细信息    查看全文

• 作者：Priti Singh^a ; ^{priti656@gmail.com}Author Vitae ; Sameer Srivastava^a ; ^{sameers@mnnit.ac.in}Author Vitae ; Parthasarathi Chakrabarti^b ; ¹ ; ^{pchakrabarti.ece@itbhu.ac.in}Author Vitae ; Sunil Kumar Singh^a ; ^{singh.sunil06@gmail.com} ; ^{singhsunil@mnnit.ac.in}Author Vitae
• 关键词：Platelets ; Microparticles ; Nanosilica ; Electrochemical sensor ; Mesoporous ; Cyclic voltammetry
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：240
• 期：Complete
• 页码：322-329
• 全文大小：2625 K
• 卷排序：240

文摘

Nanosilica-based electrochemical biosensor developed for the detection of platelet-derived microparticles (PMPs). Electrochemically deposited thionine doped silica and HRP entrapped mesoporous silica utilized for detection of platelet activation markers. Detection of PMPs through two different antibodies enhances the specificity of the sensor, minimizing the chance of false detection. Detection and quantification of PMPs provide information about platelet quality over storage. The proposed biocompatible sensor offers label-free, ease of miniaturization, and short analysis time for the detection of biomarkers.