Sustained lentiviral-mediated overexpression of microRNA124a in the dentate gyrus exacerbates anxiety- and autism-like behaviors associated with neonatal isolation in rats
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- 作者：Amine Bahi amine.bahi@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ASD ; autism spectrum disorder ; BDNF ; brain derived neurotrophic factor ; Ctr ; control ; DG ; dentate gyrus ; EPM ; elevated plus maze ; Iso ; isolated ; MBT ; marble burying test ; miR124a ; microRNA124a ; OF ; open field ; PND ; postnatal day ; SG ; self-grooming
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：311
- 期：Complete
- 页码：298-308
- 全文大小：1746 K
文摘
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Neonatal isolation induced hippocampal elevation of miR124a and reduced BDNF expression.
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Neonatal isolation decreased social interaction but increased repetitive and anxiety behaviors.
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Hippocampal miR124a overexpression exacerbated repetitive behaviors and social impairments.
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Hippocampal miR124a overexpression increased anxiety with no effect on locomotor activity.