Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future

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• 作者：Begum Alural^a ; ^b ; Sermin Genc^a ; ^b ; Stephen J. Haggarty^c ; ^d ; ^{shaggarty@mgh.harvard.edu}
• 关键词：Non-coding RNA ; MiRNA ; Schizophrenia ; Bipolar disorder ; Neuroplasticity
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2017
• 出版时间：6 February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：87-103
• 全文大小：799 K
• 卷排序：73

文摘

Multiple genetic and epigenetic factors have pivotal roles in pathogenesis of neuropsychiatric disorders. MicroRNAs (miRNAs) regulate various physiological processes in the central nervous system at the post-transcriptional level. Mutations in miRNA genes, and dysregulated miRNA expression are linked to pathogenesis of neuropsychiatric disorders. Deregulated miRNAs may be used for diagnosis, monitoring prognosis and predicting drug response.