Inhibition of store-operated calcium entry by sub-lethal levels of proteasome inhibition is associated with STIM1/STIM2 degradation
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- 作者：Xiu-li Kuanga ; b ; 1 ; Yimei Liua ; b ; 1 ; Yuhua Changa ; b ; Jing Zhoua ; b ; He Zhanga ; b ; Yiping Lic ; Jia Qua ; b ; Shengzhou Wua ; b ; wszlab@mail.eye.ac.cn" class="auth_mail" title="E-mail the corresponding author ; shzhwu1@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; disease ; PD ; Parkinson&rsquo ; s disease ; SOCC ; store-operated calcium channel ; SOCE ; store-operated calcium entry ; UPS ; ubiquitin-proteasome system ; ER ; endoplasmic reticulum ; STIM ; stromal interaction molecule ; TRPC ; canonical transient receptor potential channel ; PSMB5 ; proteasome beta subunit type-5 ; MG-132 ; carbobenzoxy-l-leucyl-l-leucyl-l-leucinal LA ; LC3 ; microtubule-associated protein light chain ; P62/SQSTM1 ; sequestosome1 ; PS ; presenilin
- 刊名：Cell Calcium
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：59
- 期：4
- 页码：172-180
- 全文大小：2129 K
文摘
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Proteasome inhibition repressed SOCE.
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Proteasome inhibition decreased STIM1 and STIM2 protein levels.
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Proteasome inhibition activated autophagy.
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Rapamycin decreased vs. bafilomycin increased STIM1/STIM2.