Adenocarcinoma of the lung with miliary brain and pulmonary metastases with echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase translocation treated with crizotinib: A case report

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• 作者：Alexander T. Falk^a ; ^b ; ^{alexander.falk.fr@gmail.com} ; Michel Poudenx^a ; Josiane Otto^a ; Hannah Ghalloussi^a ; ^b ; Jé ; rô ; me Barriè ; re^a
• 关键词：Adenocarcinoma ; Lung ; Miliary ; Brain metastases ; EML4-ALK fusion ; Crizotinib
• 刊名：Lung Cancer
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：78
• 期：3
• 页码：282-284
• 全文大小：490 K

文摘

Few descriptions of miliary brain metastases have been reported. We report the case of an adenocarcinoma of the lung associated with metachronous miliary brain and lung metastases with an echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene translocation. The patient was treated with crizotinib and showed a twelve-month progression-free survival. Clinicians should be attentive of the evolution of brain metastases with patients presenting EML4-ALK translocation.