Endoplasmatic reticulum shaping by generic mechanisms and protein-induced spontaneous curvature
详细信息 查看全文
- 作者：Erich Sackmann sackmann@ph.tum.de" class="auth_mail
- 关键词：Curvature elasticity concept of biomembrane functions ; Endoplasmatic reticulum shaping proteins ; Membrane fusion ; Membrane microtubule coupling ; Lipid protein interaction ; Reticulons ; Atlastin ; Spastin
- 刊名：Advances in Colloid and Interface Science
- 出版年：June 2014
- 年：2014
- 卷：208
- 期：Complete
- 页码：153-160
- 全文大小：1172 K
文摘
- •
The endoplasmatic reticulum (ER) is shaped and coupled to microtubules by superfamily of reticulons.
- •
Reticulons can both induce and feel high curcvatures of membranes through wedge shaped hydrophobic domains.
- •
The ER can form extended networks of tubes which can extend to the tips of axons.
- •
The connectivity of the tubular network is controlled by atlastin: a new class of fusion proteins.