Forearm vasodilator reactivity in healthy male carriers of the 3q22.3 rs9818870 polymorphism

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• 作者：Stefan Aschauer^a ; Martin Brunner^a ; Michael Wolzt^a ; Helmuth Haslacher^b ; Robin Ristl^c ; Markus Mü ; ller^a ; ^{markus.mueller@meduniwien.ac.at" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chromosome 3q22.3 ; Single nucleotide polymorphism ; Coronary artery disease ; Forearm blood flow ; Vascular function
• 刊名：Microvascular Research
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：102
• 期：Complete
• 页码：33-37
• 全文大小：303 K

文摘

A genome wide association study has identified a robust risk locus for cardiovascular disease on 3q22.3. However, the mechanisms by which the [C]/[T] polymorphism rs9818870 increases cardiovascular risk are unknown. This forearm blood flow (FBF) study addressed the question if the genetic association with cardiovascular disease in patients is preceded by incipient vasodilator impairment in young, healthy carriers of this new risk locus on chromosome 3.

Materials and methods

After a pre-screening of 74 subjects 17 male healthy volunteers homozygous/heterozygous for a single nucleotide polymorphism (SNP) risk allele on 3q22.3 and a control group of 17 healthy volunteers not carrying the allele were included into this case–control study.

Results

Forearm vascular endothelium-dependent and -independent vasodilator responses were in the normal range in both groups, although endothelium-dependent FBF reactivity to acetylcholine was significantly higher in SNP carriers of the risk allele.

Conclusion

The augmented endothelium-dependent vasodilation of the forearm resistance vasculature does not support the presence of endothelial dysfunction in young SNP carriers and indicates that other mechanisms are responsible for the strong association between coronary artery diseases and the rs9818870 polymorphism, located on 3q22.3.