Inflammation is Related to Coronary Flow Reserve Detected by Positron Emission Tomography in Asymptomatic Male Twins

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• 作者：Viola Vaccarino MD ; PhD ; ^† ; ; ^{viola.vaccarino@emory.edu} ; Durreshahwar Khan MD ; John Votaw PhD^§ ; ; Tracy Faber PhD^§ ; ; Emir Veledar PhD^† ; ; Dean P. Jones PhD^‡ ; ; Jack Goldberg PhD^¶ ; ; Paolo Raggi MD^† ; ; Arshed A. Quyyumi MD^† ; ; J. Douglas Bremner MD
• 关键词：circulation ; coronary disease ; endothelium ; imaging ; inflammation
• 刊名：Journal of the American College of Cardiology
• 出版年：2011
• 出版时间：15 March 2011
• 年：2011
• 卷：57
• 期：11
• 页码：1271-1279
• 全文大小：493 K

文摘

Objectives

This study sought to examine the relationship between inflammation and coronary microvascular function in asymptomatic individuals using positron emission tomography (PET) and assessment of coronary flow reserve (CFR).

Background

Coronary microvascular dysfunction is an early precursor of coronary artery disease (CAD) thought to result from endothelial cell activation and inflammation, but data are limited.

Methods

We examined 268 asymptomatic male monozygotic and dizygotic twins. Plasma biomarkers of inflammation and endothelial cell activation included C-reactive protein (CRP), interleukin (IL)-6, white blood cell count (WBC), vascular cell adhesion molecule (VCAM)-1, and intercellular adhesion molecule (ICAM)-1. Blood flow quantitation was obtained with [¹³N] ammonia PET at rest and after adenosine stress. CFR was measured as the ratio of maximum flow to baseline flow at rest; abnormal CFR was defined as a ratio <2.5. A summed stress score for visible perfusion defects was calculated.

Results

In within-pair analyses, all biomarkers, except VCAM-1, were higher in twins with lower CFR than their brothers with higher CFR (p < 0.05). This was observed in the entire sample, as well as within pairs discordant for a CFR of <2.5. Associations persisted after adjusting for summed stress score and CAD risk factors. In contrast no biomarker, except IL-6, was related to the summed stress score of visible defects.

Conclusions

Even in asymptomatic subjects, a decrease in coronary microvascular function is accompanied by a systemic inflammatory response, independent of CAD risk factors. Our results, using a controlled twin design, highlight the importance of coronary microvascular function in the early phases of CAD.