miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function
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- 作者：Muhammad Zaeem Nomana ; Bassam Janjib ; Guy Berchemb ; Salem Chouaiba ; salem.chouaib@gustaveroussy.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIF ; hypoxia-inducible factor ; O2 ; oxygen ; miRNAs ; microRNAs ; miR-210 ; microRNA-210 ; HRM ; hypoxia regulated miRNAs ; MVs ; microvesicles ; EVs ; extracellular vesicles ; EXs ; exosomes ; HMVs ; hypoxic microvesicles ; TGF-β ; transforming growth factor-β ; CTL ; cytotoxic T lymphocyte ; NK ; natural killer cells
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 September 2016
- 年：2016
- 卷：380
- 期：1
- 页码：257-262
- 全文大小：1019 K
文摘
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Hypoxia is a hallmark of all solid tumors favoring metastasis and poor prognosis.
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Hypoxia-induced miR-210 is a master regulator of hypoxic tumor response.
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We showed that miR-210 fine tunes the tumoral response to hypoxia.
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Exosomes and microvesicles released from hypoxic tumor regulate killer cell function.
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This review outlines how killer function depends on miR-210 and hypoxic microvesicles.